R Clinton Webb Selected Research

Rho Guanine Nucleotide Exchange Factors

4/2010	Up-regulation of the RhoA/Rho-kinase signaling pathway in corpus cavernosum from endothelial nitric-oxide synthase (NOS), but not neuronal NOS, null mice.
10/2009	PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA.
8/2007	Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.
8/2007	Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats.
3/2006	Angiotensin II up-regulates the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF), a regulator of G protein signaling domain-containing RhoGEF, in vascular smooth muscle cells.
10/2005	Proerectile effects of the Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis.
10/2004	Increaseed expression of mRNA for regulator of G protein signaling domain-containing Rho guanine nucleotide exchange factors in aorta from stroke-prone spontaneously hypertensive rats.

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R Clinton Webb Research Topics

Disease

56	Hypertension (High Blood Pressure) 01/2022 - 07/2002
21	Erectile Dysfunction 01/2021 - 12/2002
12	Cardiovascular Diseases (Cardiovascular Disease) 10/2019 - 07/2002
9	Inflammation (Inflammations) 01/2018 - 07/2002
8	Stroke (Strokes) 03/2019 - 10/2004
6	Obesity 01/2021 - 05/2008
5	Vascular Diseases (Vascular Disease) 09/2021 - 01/2009
5	Leukemia 04/2010 - 10/2005
4	Body Weight (Weight, Body) 01/2021 - 06/2008
4	Pre-Eclampsia (Preeclampsia) 01/2020 - 10/2010
4	Sepsis (Septicemia) 01/2019 - 04/2015
4	Hypotension (Low Blood Pressure) 01/2018 - 07/2003
4	Type 2 Diabetes Mellitus (MODY) 07/2015 - 11/2010
3	COVID-19 10/2021 - 01/2021
3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 03/2019 - 01/2003
2	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2019 - 12/2017
2	Septic Shock (Toxic Shock Syndrome) 01/2018 - 05/2009
2	Neoplasms (Cancer) 11/2017 - 11/2010
2	Endotoxemia 06/2016 - 05/2009
2	Hemorrhagic Shock 01/2016 - 04/2015
2	Lung Injury 01/2016 - 04/2015
2	Fibrosis (Cirrhosis) 03/2014 - 01/2013
2	Vascular Remodeling 01/2014 - 01/2014
2	Necrosis 08/2013 - 10/2012
2	Insulin Resistance 03/2013 - 11/2010
2	Hyperglycemia 11/2010 - 02/2009
2	Ischemic Stroke 02/2004 - 01/2003
2	Infarction (Infarctions) 02/2004 - 01/2003
1	Bites and Stings (Sting) 01/2021
1	Familial Testotoxicosis 01/2021
1	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 02/2020
1	Hemorrhage 03/2019

Drug/Important Bio-Agent (IBA)

14	rho-Associated KinasesIBA 06/2013 - 12/2002
12	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 07/2002
12	Proteins (Proteins, Gene)FDA Link 01/2018 - 05/2007
10	SaltsIBA 02/2014 - 01/2008
9	Angiotensin IIIBA 03/2014 - 03/2006
8	CytokinesIBA 01/2021 - 08/2008
8	Vasoconstrictor AgentsIBA 01/2018 - 07/2003
7	Rho Guanine Nucleotide Exchange FactorsIBA 04/2010 - 10/2004
6	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2022 - 03/2013
5	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 01/2019 - 04/2015
5	Desoxycorticosterone Acetate (DOCA)FDA Link 01/2013 - 06/2008
4	Pattern Recognition ReceptorsIBA 01/2021 - 01/2016
4	Toll-Like Receptor 4IBA 01/2020 - 12/2016
4	Endothelin-1 (Endothelin 1)IBA 09/2011 - 07/2004
3	Toll-Like Receptor 9IBA 01/2021 - 10/2012
3	Soluble Guanylyl CyclaseIBA 01/2021 - 12/2011
3	Glucose (Dextrose)FDA LinkGeneric 03/2019 - 11/2010
3	Interleukin-10 (Interleukin 10)IBA 02/2019 - 08/2008
3	Peptides (Polypeptides)IBA 01/2019 - 04/2015
3	Antihypertensive Agents (Antihypertensives)IBA 11/2016 - 03/2012
3	Mitochondrial DNA (mtDNA)IBA 01/2016 - 10/2012
3	Desoxycorticosterone (Deoxycorticosterone)IBA 01/2013 - 06/2008
3	Acetates (Acetic Acid Esters)FDA Link 01/2013 - 06/2008
3	MineralocorticoidsIBA 01/2013 - 02/2009
3	ArginaseIBA 01/2013 - 03/2011
3	CalciumIBA 11/2010 - 02/2009
3	Messenger RNA (mRNA)IBA 04/2010 - 10/2004
3	3- (4- Amino- 5- cyclopropylpyrimidine- 2- yl)- 1- (2- fluorobenzyl)- 1H- pyrazolo(3,4- b)pyridineIBA 05/2009 - 03/2006
3	Vasodilator Agents (Vasodilators)IBA 02/2009 - 07/2002
3	Superoxides (Superoxide)IBA 08/2008 - 01/2004
3	Nitric Oxide Synthase (NO Synthase)IBA 10/2005 - 07/2002
3	sapropterin (tetrahydrobiopterin)FDA Link 01/2004 - 07/2002
2	BradykininIBA 01/2021 - 01/2021
2	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2020 - 03/2008
2	IronIBA 03/2019 - 02/2004
2	EnzymesIBA 01/2019 - 11/2011
2	Superoxide DismutaseIBA 01/2018 - 02/2004
2	AntioxidantsIBA 01/2018 - 05/2009
2	Chloroquine (Aralen)FDA LinkGeneric 02/2017 - 11/2016
2	DNA (Deoxyribonucleic Acid)IBA 04/2016 - 01/2016
2	ThromboxanesIBA 01/2016 - 06/2012
2	Clopidogrel (Plavix)FDA Link 01/2014 - 04/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2012 - 10/2004
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 12/2011 - 01/2010
2	Endothelins (Endothelin)IBA 02/2009 - 01/2008
2	GTP-Binding Proteins (G-Protein)IBA 03/2006 - 10/2004
2	GlucocorticoidsIBA 03/2003 - 07/2002
1	Toll-Like Receptor 3IBA 10/2021
1	HydrogenIBA 09/2021
1	Protein AggregatesIBA 01/2021
1	InterferonsIBA 01/2021
1	Blood Glucose (Blood Sugar)IBA 01/2021
1	Testosterone (Sustanon)FDA Link 01/2021
1	Apomorphine FDA Link 01/2021
1	4-(fluoromethyl)phenyl phosphate (FMPP)IBA 01/2021
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2021
1	Nucleic AcidsIBA 01/2020
1	Ion Channels (Ion Channel)IBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Retinaldehyde (Retinal)IBA 10/2019
1	ChemokinesIBA 10/2019
1	Sulfates (Sulfates, Inorganic)IBA 03/2019
1	Oxygen (Dioxygen)IBA 03/2019
1	ethyl 6- (N- (2- chloro- 4- fluorophenyl)sulfamoyl)cyclohex- 1- ene- 1- carboxylateIBA 03/2019
1	EquilinIBA 01/2019
1	Adrenergic Agonists (Adrenergic Receptor Agonist)IBA 01/2019

Therapy/Procedure

10	Therapeutics 01/2019 - 03/2006
2	Resuscitation 01/2019 - 01/2018